chapter1.8
A Trial of Aloes Compound (Indian Indigenous Drug) in Case of Menstrual Irregularity Associated with Sterility
by
KRISHNA MUKHERJEE;,
M.S.
M. PANDE,
M.S.
and
M. MUKHERJI,
M.D. F.R.C.O.G.
Lecturer, Department of Obst. & Gyn.
Registrar Department of Obst. & Gyn.
Professor and Head of the Department of Obstetrics and Gynaecology,
M.L.N. Medical College, Allahabad.
Irregular scanty menses is a fairly common problem which a Gynaecologist meets with. Frequently these complaints are associated with primary or secondary sterility. About 10% of sterile marriages no fault can be found in both the partners. (Brown 1964)
In such cases simple advice sometimes does good. Some authors speak of "psychogenic sterility" in which mental stress due to anxiety, worry or other emotional situations cause tubal spasm or even anovulation (hypothalamic amenorrhoea).
In such the physician by establishing a sympathetic and understanding relationship with his patient may unconsciously assume the role of psychotherapist, which may explain why many hitherto sterile women become pregnant during the course of investigation." (Bos and Cleghorn 1958).
Jeffcoate (1969) emphasises that "Psychological factors may fail to suppress a stable ovarian and uterine cycle completely and sometimes succeed only in reducing the amount of flow. The best example is pseudocyesis—which is frequently characterized by scanty period rather than amenorrhoea".
Sterile woman becomes more apprehensive, tense and mentally upset, which usually makes the menstrual cycle irregular or scanty. It is not clear whether the sterility is caused because of irregular or scanty periods or such menstrual disturbances are because of sterility.
Keeping the above facts in mind a trial of Aloes compound was made.
Material and Method
Cases of primary and secondary sterility with the history of irregular or scanty periods were collected from Kamla Nehru Memorial Hospital, Allahabad. The cases were grouped as follows:
1. Primary sterility:
- A. Oligomenorrhoea — 20 cases
- B. Irregular periods — 30 cases
Total stated in source: 59 cases
2. Secondary sterility — 50 cases
- A. Oligomenorrhoea — 15 cases
- B. Irregular periods — 35 cases
A thorough history was taken specially regarding the menstrual pattern, duration for which it has become irregular and fertility state of brothers and sisters.
Proper, general systemic and local examination was carried out. Premenstrual endometrial biopsy, postmenstrual hysterosalpingography and semen analysis of every couple was done and the cases where there was any organic cause for sterility or menstrual irregularity were excluded from the study.
Selected cases were given "Aloes compound" for six consecutive cycles.
Pharmacology of the Drug
The drug contains following ingredients:
The ingredient table/content is not present in the supplied source text.
| Types of Cases | Total number of cases | Improvement within 3 Cycles | |
|---|---|---|---|
| Number | Percentage | ||
| 1. Oligomenorrhoea | |||
| (a) Primary sterility | 20 | 17 | 85% |
| (b) Secondary sterility | 15 | 11 | 73.3% |
| 2. Irregular Periods | |||
| (a) Primary sterility | 30 | 26 | 86.6% |
| (b) Secondary sterility | 35 | 29 | $2.$% |
TABLE 2
| Type of Cases | Total number of cases | Cases conceived — Number | Percentage |
|---|---|---|---|
| 1. Primary sterility | 50 | 8 | 16% |
| 2. Secondary sterility | 50 | 5 | 10% |
Secondary sterility. It gives encouraging results in apprehensive and tense patients, who are over concerned for their menstrual irregularity.
In the present study the conception rate is low, 16% and 10% in primary and secondary sterility respectively, in contrast with the results of Dr. Bulsara (1966) who reported pregnancy in 30 cases out of 45 cases of primary sterility and in 1 case out of 5 cases of secondary sterility.
The low conception rate noted in the present series might be because of short follow up, (The maximum follow up period being 10 months). The rest of the cases are still under observation.
Acknowledgement
We are thankful to M/s. Alarsin Pharmaceuticals, Bombay-1 (B.R.) for supplying us with the tablets of Aloes compound, by the kind co-operation of Mr. K. S. Mehrotra. (Supervisor) & Mr. Niraj Kumar (Medical Representative), Allahabad.
References
- Bos, C. and Cleghorn, R. A.: Fertil and steril. 9: 84, 1958. Quoted by Browne, F. J. and Browne, J. C., McLure. "Post-graduate Obstetrics and Gynaecology" 3rd Ed. (1964) Butterworth & Co. (Publishers) Ltd.
- Browne, F. J., Browne, J. C. and McLure: "Post-graduate Obstetrics and Gynaecology" 3rd Ed. (1964) Butterworth & Co. (Publishers) Ltd.
- Bulsara Roshan R. (1966) sterility Associated with Irregular and scanty menstruation. Ind. Prac., 19: 1-123-5 Jan. 1966.
- Jeffooate, T. N. A.: "Princtiples of Gynaecology" 3rd Ed. (1969) Butterworth & Co. (Publishers) Ltd.