chapter1.4

For the use only of a registered medical practitioner or a hospital or a laboratory.

Management of Couple Infertility with Aloes Compound* In Females, and Fortege* In Males in a Rural Area

By

L. R. Das, MABS., Fh. D., LAMS.
At Padhan Pali, P. O. Patkulanda,
Dist. Sambalpur, Orissa

Introduction

A family with a large number of children is an economic problem facing the over-populated underdeveloped countries while the absence of a child in the family is a social problem as the parents feel distressed for not having a child, irrespective of their social status, whether rich, middle-class or poor.

In the urban population facilities for investigations with sophisticated methods are fairly available. The vast majority of Indian population (80%) is rural.

While only 20% of those living in towns and cities enjoy better medical facilities favorably comparable to Western standards, 80% forming the rural population do not have access to these facilities. A medical practitioner practicing in the rural area has to manage things to the best of his abilities.

Review of Literature on Aloes Compound

Balsara, Jhaveri, Mukherjee and Agrawal have reported successful results with Aloes Compound in Sterility associated with menstrual disorders. Gupta, Rajasekharan, Sivaraman, Shah, Sangamnerkar, Panda and Khosla reported good results with Aloes Compound in the management of Primary and Secondary Sterility and the Conception Rates given in all these studies were good.

These studies encouraged the author to select Aloes Compound for the present study.

Review of Literature on Fortege in Male Infertility

Gupta, Shelat, Bhalerao, Jagadisan and Pande tried Fortege in cases of oligospermia and cases of uncomplicated Male Infertility and reported good Conception Rates in their spouses.

The author wishes to say that he and his wife were a case of Couple Infertility and formed a part of this study.

Aloes Compound (Alarsin)

Each tablet of Aloes Compound contains in mg:

Ingredient Quantity
Aloes (Aloes indica) 70 mg
Hira Bol (Balsamodendron myrrha) 70 mg
Kamboji (Breynia patens) 30 mg
Manjishta (Rubia cordifolia) 35 mg
Harmal (Pegum'rn Harmala) 35 mg
Kasis (Ferrisulphas) 30 mg
Jeevanti (Leptadenia reticulata) 30 mg

Aloes was investigated by Satyavali et al. It was found to improve menstrual functions and conception rate was 85% among infertile women.

Aloes corrects menstrual disorders and regulates the flow and rhythm of monthly periods; causes timely ovulatory cycles. It has no disadvantages of hormonal drugs.

Fortege (Alarsin)

Each tablet of Fortege contains in mg:

Ingredient Quantity
Kamboji (Breynia patens) 56 mg
Kauncha Beej (Mucuna pruriens) 30 mg
Suddha Kachura (Detoxicated Strychnos nuxvomica) 30 mg
Samudra sosh Beej (Argyria speciosa) 15 mg
Vardhara Beej (Rourea santaloides - seeds) 15 mg
Laving (Carvophyllus aromaticus) 7.5 mg
Vardhara Mool (Rourea santaloides - root) 15 mg
Asan (Withania somnifera) 15 mg
Pipar (Piper longum) 7.5 mg
Vacha (Acorus calamus) 7.5 mg
Mari (Piper nigrum) 7.5 mg
Sunth (Zingiber officinalis) 7.5 mg
Chitri kabab (Cubeb officinalis) 7.5 mg
Alcaiakara (Anacyclus pyrethrum) 7.5 mg
Sukhedver (Santalum album) 7.5 mg
Jaiphal (Myristica fragrans) 4.5 mg
Javantha (Myristica fragrans - arillus) 3.0 mg
Jeevanati (Leptadenia reticulata) 56.5 mg

Fortege tones up neuro-glandular, neuro-muscular, genito-urinary and gastro-intestinal systems. Relieves fatigue. Improves sex performance, keeps one fresh, alert, active and vigorous.

Materials & Methods

This study was done during 1980-84 at my own village and purely in rural conditions. This is a study of 40 cases of Infertility treated with Aloes Compound in females and Fortege in males.

Female infertility was diagnosed by menstrual history and clinical examination. Eleven among them had already taken hormonal treatment without success. One woman had Mantra Chikitsa without benefit.

The rest of the women had tried many herbs as home remedies for their infertility which gave no results.

In all cases of Female Infertility, the male was also investigated without exception. The only test done and the criterion for Male Infertility was the semen analysis.

From these, three classifications were made: Female Infertility; Male Infertility and Couple Infertility where both the partners were infertile.

Dysmenorrhoea, hypermenorrhoea and scanty menses were the common causes for Female Infertility.

One case had gonococcal infection and was treated with antibiotics before treatment for infertility. It was couple infertility (Primary) and so the male partner was also similarly treated for gonococcal infection.

One male patient had syphilis. His wife was also examined and both were treated with antibiotics for the same, before treatment for infertility (Secondary) was started.

Semen analysis was done before starting Fortege treatment and later once a month, and the last one being after four months of treatment.

Female Infertility was treated with Aloes Compound and Male Infertility was treated with Fortege. Females were treated till conception and males were treated for four months.

In Female Infertility only the woman was treated and the husband was not given any treatment. In Male Infertility, only the man was treated and no drug was given to his wife. In Couple Infertility, both the husband and wife were treated accordingly.

Treatment was stopped immediately as pregnancy was suspected. The maximum period of observation was 10 months.

All the deliveries were done under our care except one.

Age Groups: Females

Majority of cases, 31 (77.5%) females were in the Age Groups of 20-30 years.

TABLE I — Age Groups: Females. N = 40

Age Group No. of Cases %
20-25 Yrs. 16 40.0%
26-30 Yrs. 15 37.5%
31-35 Yrs. 4 10.0%
36-40 Yrs. 3 7.5%
41-45 Yrs. 1 2.5%
45-50 Yrs. 1 2.5%
Total 40 100.0%

Age Groups: Males

Majority of cases, 33 males were in the Age Groups of 21-35 years.

TABLE II — Age Groups: Males. N = 40

Age Group No. of Cases %
21-25 Yrs. 7 17.5%
26-30 Yrs. 13 32.5%
31-35 Yrs. 13 32.5%
36-40 Yrs. 3 7.5%
41-45 Yrs. 2 5.0%
46-50 Yrs. 1 2.5%
51-55 Yrs. 1 2.5%
Total 40 100.0%

Duration of Married Life

Majority of couples, 32 (80%) had married life of 6-15 years.

TABLE III — Duration of Married Life. N = 40

Duration No. of Cases %
3-5 Yrs. 2 5.0%
6-10 Yrs. 18 45.0%
11-15 Yrs. 14 35.0%
16-20 Yrs. 3 7.5%
21-25 Yrs. 1 2.5%
26-30 Yrs. 2 5.0%
Total 40 100.0%

Female, Male & Couple Infertility

There were 8 cases (20%) of Female Infertility, 10 cases (25%) of Male Infertility and 22 cases (55%) of Couple Infertility where both the partners had to be treated for infertility.

TABLE IV — Female, Male & Couple Infertility. N = 40

Infertility No. of Cases %
Female Infertility 8 20.0%
Male Infertility 10 25.0%
Couple Infertility 22 55.0%
Total 40 100.0%

Primary or Secondary Sterility

There were 16 cases (40%) of Primary Sterility and 24 cases (60%) of Secondary Sterility.

Sterility Primary % Secondary % Total %
Wife 5 12.5% 3 7.5% 8 20.0%
Husband 2 5.0% 8 20.0% 10 25.0%
Couple 9 22.5% 13 32.5% 22 55.0%
Total 16 40% 24 60% 40 100%

Semen Analysis

The husband did not come for examination and only wife came with the complaint of infertility. The author insisted on the semen analysis of all the husbands without exception.

Only 8 men had sperm count of over 60 mlns./ml. In about one third of the patients, namely 15 (37.5%), sperm count was less than 20 mlns./ml. Sperm Motility in the majority of cases was less than 40%.

TABLE VI — Sperm Count Before Starting Treatment. N = 40

Sperm Count No. of Cases %
5-10 mln/ml 5 12.5%
11-20 mln/ml 10 25.0%
21-40 mln/ml 6 15.0%
41-60 mln/ml 11 27.5%
Over 60 mln/ml 8 20.0%
Total 40 100.0%

Treatment in Female Infertility with Aloes Compound

In Female Infertility, Aloes Compound 2 tabs, three times a day was continuously given till pregnancy was suspected when the drug was immediately discontinued.

The maximum period was 9 months. As a precaution against any abortion or miscarriage Leptaden (Alarsin) was given throughout pregnancy in a dose of 1 or 2 tabs two, or three times a day.

If no conception took place within 9 months of treatment, the case was deemed a failure.

Treatment in Male Infertility With Fortege

In Male Infertility, Fortege 2 tabs, three times a day was given continuously for four months.

Semen analysis was done once a month. If semen picture did not improve within 4 months of Fortege treatment the case was deemed a failure.

In a few cases where non-specific urinary tract infection was suspected, Bangshil (Alarsin), 1 tab, three times a day was also given with Fortege.

Results of Treatment

Conception Rate

Out of 40 women 38 women (95%) conceived and only 2 women (5%) did not conceive.

TABLE VII — Results of Aloes Compound Treatment in Females & Fortege in Males. N = 40

Conception No. of Cases %
Conceived 38 95.0%
Not conceived 2 5.0%
Total 40 100.0%

Duration of Treatment For Conception

In 10 women (26.3%) conception took place within 4 months; 21 women (55.3%) conceived between 5th and 7th months and 7 women (18.4%) conceived between 8th and 10th months of observation.

The maximum period of treatment was 9 months, and the observation period for conception was one month more.

TABLE VIII — Conceived in So Many Months With Aloes Compound in Females and Fortege in Males. N = 38

Conceived In No. of Cases %
4th Month 10 26.3%
5th-7th months 21 55.3%
8th to 10th month 7 18.4%
Total 38 100.0%

Conception Rates in Female Infertility, Male Infertility & Couple Infertility

Among 8 cases of Female Infertility, 7 cases (87.5%) conceived and only 1 woman (12.5%) did not conceive.

Among 10 cases of male infertility, all the wives conceived (100%).

Among 22 cases of Couple Infertility 21 women (95.5%) conceived and only 1 woman (4.5%) did not conceive.

On the whole 38 women (95%) conceived and only two women (5%) did not conceive.

Out of these 2 women who did not conceive, one was a case of Female Infertility and other was the case of Couple Infertility.

TABLE IX — Conception Rates of Female Infertility, Male Infertility & Couple Infertility. N = 40

Infertility No. of Cases Conceived % Not Conceived % 4-7-10 Months
Female Infertility 8 7 87.5% 1 12.5% 1 + 4 + 2
Male Infertility 10 10 100.0% 0 - 1 + 8 + 1
Couple Infertility 22 21 95.5% 1 4.5% 8 + 9 + 4
Total 40 38 95.0% 2 5.0% 10 + 21 + 7

Discussion

Out of 38 conceptions, 3 were delivered by caesarean, 5 were delivered by help of Forceps and 30 were normal deliveries.

Out of these normal deliveries, there were 3 still-births.

The weights of children born ranged from 1.500 kg to 2.500 kg and the mean baby weight was 2.100 kg.

Conclusion and Summary

In the management of Female Infertility, Male infertility and Couple Infertility in purely Rural Area and Rural conditions, Aloes Compound in Females and Fortege in Males, are found to be of immense benefit where sophisticated investigations are unavailable.

Female Infertility was diagnosed clinically and Male infertility was diagnosed only by one test, that is Semen Analysis.

Overall conception rate reported in the study:
38 cases out of 40 cases — 95%.

Overall conception rate was 95% that is 38 cases of infertility, primary or secondary, conceived out of the total 40 cases.

No toxic or side effects were observed in the use of these drugs in parents or in their offspring.

Acknowledgement

I am thankful to Mr. P.G. Shukla of Alarsin Marketing Pvt. Ltd. Bombay 400 023.

References

1. Balsara, Roshan R. (1966): “Sterility associated with Irregular and scanty menstruation (Use of Aloes Compound as an adjuvant)”, Indian Practitioner, 19:1, pp. 123-125, Jan 1966.

2. Jhaveri C.L.; Mody, Ila; Munim, J.K. and Dass, F.G. (1972): “Clinical Evaluation of Infertility associated with irregular Menstrual Cycles treated with an Indigenous preparation”, XVI All India Obst. & Gynec. Congress, New Delhi, 10-12 March 1972.

3. Mukherjee, Krishna; Pande, M.; Mukherjee, Meena (1972): “A trial of Aloes Compound (an indigenous drug) in cases of sterility associated with Menstrual Irregularity”, XVI All India Obst. & Gynec. Congress, New Delhi, 10-12 March 1972.

4. Agrawal, R.S. (1979): “A controlled trial of Aloes Compound in cases of sterility and Menstrual Irregularity”, 1st Asian Congress of Induced Abortion & Voluntary Sterilisation, Bombay, 4-9 March 1970.

5. Gupta, Kusum (1972): “Aloes Compound (A herbal drug) in Functional Sterility”, XVI All India Obst. & Gynaec. Congress, New Delhi, 10-12 March 1972.

6. Rajasekharan, N.; Vijaya, R.; White, Ceilia Dorothy; Rani, Uma (1975): Trial with Indigenous drug Aloes Compound in Infertility, Antiseptic, Vol. 72:2, pp. 451-457, Sept. 1975.

7. Sivaraman, Ramani; Kumari, Sujaya; Kannan, Usha; Dharthi (1976): “Aloes Compound in Sterility”, Antiseptic, 73:7, pp. 366-370, July 1976.

8. Shah, Bakula P. (1977): “Management of Primary and Secondary Sterility till delivery with Aloes Compound & Leptaden in the mofussil and rural areas in India”, 21st All India Obst. & Gynec. Congress, Cuttack, 27-29 Dec. 1977; Antiseptic, 77:3, pp. 155-162, March 1980.

9. Shah, Bakula P. & Shah, Pramod H. (1980): “Non-hormonal Ayurvedic Drugs in the treatment of Primary Infertility”, 1st National Congress on Hormones and Human Reproduction, Bombay, 22-25 Nov. 1980; Current Medical Practice, Vol. 26:12, pp. 363-366, Dec. 1982.

10. Sangamnerkar, A.V. (1977): “Aloes Compound in Sterility”, 21st All India Obst. & Gynec. Congress, Cuttack Orissa, 27-29 Dec. 1977; Antiseptic, 76:1, pp. 22-27, Jan. 1979.

11. Panda, B.C.; Pradhan, S.N. and Parida, H.K. (1981): “Aloes Compound and Ayurvedic Drug in the management of Female Infertility – A controlled study”, 56th All India Med. Conf., Cuttack, Orissa, 28-31 Dec. 1980.

12. Panda, Bishnu Charan; Pradhan, S.N. and Parida, H.K. (1981): “Aloes Compound in the Management of female Infertility (A Comparative Study with Hormones)”, XXV All India Obst. & Gynec. Congress, Calcutta, 29-31 Dec. 1981; Medicine & Surgery, XXII:5, pp. 41-43, May 1982.

13. Khosla, Usha (1981): “Management of Primary & Secondary Sterility with (1) Aloes Compound (2) D&C/Aloes Compound (3) D&C/Aloes Compound with Inj. Placentrex”, Medicine & Surgery, Vol. XX:7, pp. 22-26, July 1981.

FORTEGE — Male Infertility, Functional Impotence, Oligospermia

14. Gupta, L.N. (1975): “Role of Fortege in Oligospermia”, Current Medical Practice, 19:6, p. 272-73, June 1975.

15. Shelat, R.K.; Majumdar, Muktiben; Banderia, Bhartiben; Basu, K.N. (1977): “Usefulness of Fortege in Oligospermia & Low Motility of Sperms (A Controlled Trial)”, First Asian Congress of Fertility & Sterility, Bombay, 19-23 Feb. 1977.

16. Bhalerao, Mohan N. & Bhalerao, Savitha M. (1979): “An Ayurvedic drug Fortege in the treatment of Oligospermia”, 19th Maharashtra State Medical Conference, Bombay, 2-4 Nov. 1979.

17. Bhalerao, Mohan N.; Bhalerao, Savitha M. & Daithankar, S.G. (1979): “Fortege in Male Infertility - A Controlled Trial”, 23rd All India Obst. & Gynec. Congress, Bangalore, 29-31 Dec. 1979; Current Medical Practice, 24:3, p. 95-99, March 1980.

18. Jagadisan, D.; Satyanarayan, A.M.; Sivaji & Vijayan (1981): “Fortege in Male Infertility due to Oligospermia (Trial with a non-hormonal Ayurvedic drug in Infertile Couples)”, Antiseptic, 78:12, p.678, Dec. 1981.

19. Panda, B.C.; Behera, Manojkumar; Pradhan, Sachidananda; Maharana, Indrajit (1982): “Management of Male Infertility with Fortege - an Ayurvedic Drug (A Double Blind Crossover Study)”, XXVI All India Obst. & Gynec. Congress, Pune (Mah.), 29-31 Dec. 1982.

Important:

This section reproduces information from a historical study published on the Alarsin website. The study describes its methodology and reported outcomes from cases treated during 1980-84. The reported results should be understood in the context of that historical study and should not, by themselves, be interpreted as current clinical evidence or a medical recommendation.

The original source states that the material is for use only by a registered medical practitioner, hospital or laboratory.